Jackson County is a rural community primarily composed of business in agriculture, manufacturing, service, and retail trade. In addition, many government facilities are located within the county, including a federal prison and three state correctional institutions. Elevation ranges from 50 to 330 feet above sea level. Marianna is 185 feet above sea level.

Soil composition ranges from sandy to clay base. The most typical soil is sandy loam. Jackson County has a vast deposit of nearly pure limestone. The county abounds in lakes including Lake Seminole, Compass Lake, Merritt's Mill Pond and Ocheessee Pond. The Chattahoochee-Apalachicola River, which is navigable and has a nine foot channel depth, forms the county's eastern border. The Chipola River flows south through the center of the county.